Meshorer LabHebrew University

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Publications

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Full publication list on PubMed

Selected articles

Reviews and commentaries

By downloading the following papers you agree that the PDF is for personal use only.

 

    2017
    Link to PDF Harikumar A*, Edupuganti RR*, Sorek M, Azad GK, Markoulaki S, Sehnalová P, Legartová S, Bártová E, Farkash-Amar S, Jaenisch R, Alon U & Meshorer E (2017) An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells. Stem Cell Reports, 9(3):1-11

    Link to PDF Edupuganti RR*, Harikumar A*, Aaronson Y, Biran A, Sailaja BS, Nissim-Rafinia M, Azad GK, Cohen MA, Park JE, Shivalila CS, Markoulaki S, Sze SK, Jaenisch R & Meshorer E (2017) Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation. Stem Cell Reports. 9(13):1-13

    Link to PDF Schlesinger S, Kaffe B, Melcer S, Aguilera JD, Sivaraman DM, Kaplan T & Meshorer E (2017) A hyperdynamic H3.3 nucleosome marks promoter regions in pluripotent embryonic stem cells. Nucleic Acids Res, in press

    2016
    Link to PDF Torres CM*, Biran A*, Burney MJ, Patel H, Henser-Brownhill T,Shapira Cohen A-H, Li Y, Ben-Hamo R,Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E & Scaffidi P (2016) The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity. Science, 353(6307):1514

    Preview by Almouzni et al.:

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    • The Epigenome and Cancer Stem Cell Fate: Connected by a Linker Histone Variant

    Link to PDF Aaronson Y, Livyatan I, Gokhman D & Meshorer E (2016) Systematic identification of gene family regulators in mouse and human embryonic stem cells. Nucleic Acids Res, 44(9):4080-9

    Link to PDF Gokhman D, Meshorer E & Carmel L (2016) Epigenetics: It's Getting Old. Past Meets Future in Paleoepigenetics. Trends Ecol Evol, 31(4):290-300

    2015
    Link to PDF Livyatan I, Aaronson Y, Gokhman D, Ashkenazi R & Meshorer E (2015) BindDB: An integrated database and webtool platform for “Reverse-ChIP” epigenomic analysis. Cell Stem Cell, 17(6):647-648

    Link to PDF Harikumar A & Meshorer E (2015) Chromatin remodeling and bivalent histone modifications in embryonic stem cells. EMBO Rep. 15(12):1609-1619

    Link to PDF Mattout A, Aaronson Y, Sailaja BS, Raghu Ram EV, Harikumar A, Mallm JP, Sim KH, Nissim-Rafinia M, Supper E, Singh PB, Sze SK, Gasser SM, Rippe K & Meshorer E (2015) Heterochromatin Protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells.. Genome Biol, 16(1):213-233

    Link to PDF Kfir N, Lev-Maor G, Glaich O, Alajem A, Datta A, Sze SK, Meshorer E, Ast G (2015) SF3B1 Association with Chromatin Determines Splicing Outcomes. Cell Rep, 11(4):618-629

    Link to PDF Alajem A, Biran A, Harikumar A, Sailaja BS, Aaronson Y, Livyatan I, Nissim-Rafinia M, Sommer AG, Mostoslavsky G, Gerbasi VR, Golden, DE, Datta A, Sze SK & Meshorer E (2015) Differential association of chromatin proteins identifies BAF60a/SMARCD1 as a regulator of embryonic stem cell differentiation. Cell Rep, 10(12):2019-2031

    Link to PDF Moussaieff A, Rouleau M, Kitsberg D, Cohen M, Levy G, Barasch D, Nemirovski A, Shen-Orr S, Laevsky I, Amit M, Bomze D, Elena-Herrmann B, Scherf T, Nissim-Rafinia M, Kempa S, Itskovitz-Eldor J, Meshorer E, Aberdam D & Nahmias Y (2015) Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells. Cell Metab, 21(3):392-402

    Preview by Daley et al.:

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    • Metabolic switches linked to pluripotency and embryonic stem cell differentiation

    Link to PDF Yearim A, Gelfman S, Shayevitch R, Melcer S, Glaich O, Mallm JP, Nissim-Rafinia M, Cohen AS, Rippe K, Meshorer E & Ast G (2015) HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing. Cell Rep, 10(7):1122-34

    2014
    Link to PDF Bošković A, Eid A, Pontabry J, Ishiuchi T, Spiegelhalter C, Raghu Ram EV, Meshorer E, Torres-Padilla ME (2014) Higher chromatin mobility supports totipotency and precedes pluripotency in vivo. Genes Dev, 28(10):1042-7

    Link to PDF Gokhman D, Lavi E, Prüfer K, Fraga MF, Riancho JA, Kelso J, Pääbo S, Meshorer E and Carmel L (2014) Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan. Science, 344(6183):523-7

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    • How to build a Neanderthal / Nature


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    • Ancient DNA Holds Clues to Gene Activity in Extinct Humans / Science


    Link to PDF Schlesinger S, Meshorer E and Goff SP (2014) Asynchronous transcriptional silencing of individual retroviral genomes in embryonic cells. Retrovirology, 11(1):31

    Link to PDF Ben-David U, Biran A, Scaffidi P, Herold-Mende C, Boehringer M, Meshorer E and Benvenisty N (2014) Elimination of undifferentiated cancer cells by pluripotent stem cell inhibitors. J Mol Cell Biol, 6(3):267-9

    Link to PDF Bodaker M, Meshorer E, Mitrani E and Louzoun Y (2014) Genes related to differentiation are correlated with the gene regulatory network structure. Bioinformatics, 30(3):406-13

    Link to PDF Meshorer E (2014) Epigenetics one stem at a time. Cell Stem Cell. 14(6):708

    2013
    Link to PDF Livyatan I, Harikumar A, Nissim-Rafinia M, Duttagupta R, Gingeras TR and Meshorer E (2013) Non-polyadenylated transcription in embryonic stem cells reveals novel non-coding RNA related to pluripotency and differentiation. Nucl. Acids Res, 41(12):6300-15 [Featured article - Cover]
    Link to PDF Gokhman D, Livyatan I, Sailaja BS, Melcer S and Meshorer E (2013) Multilayered chromatin analysis reveals E2f, Smad and Zfxas transcriptional regulators of histones. Nat Struct Mol Biol, 20(1):119-26

    Link to PDF Livyatan I and Meshorer E (2013) SON sheds light on RNA splicing and pluripotency. Nat Cell Biol. 15, 1139–1140

    Link to PDF Harikumar A and Meshorer E (2013) Measuring the dynamics of chromatin proteins during differentiation. Methods Mol Biol. 1042, 173-80.

    Link to PDF Meshorer E (2013) SyStem cell biology, A systems biology approach to pluripotent stem cells. Systems Biomed 1:1-3

    Link to PDF Livyatan I and Meshorer E (2013) The HDAC interaction network. Mol Syst Biol 9, 671

    Link to PDF Aaronson Y and Meshorer E (2013) Stem cells: Regulation by alternative splicing. Nature 498, 176-177

    2012
    Link to PDF Sailaja BS, Cohen-Carmon D, Zimmerman G, Soreq H and Meshorer E (2012) Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4. Proc Natl Acad Sci U S A, 109(52):E3687-95

    Link to PDF Melcer S, Hezroni H, Nissim-Rafinia M, Rand E, Skoultchi A, Stewart C L, Bustin M and Meshorer E (2012) Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation. Nat Commun 3:910. [Featured Image]

    Link to PDF Shahar OD, Ram EV, Shimshoni E, Hareli S, Meshorer E and Goldberg M (2012) Live imaging of induced and controlled DNA double-strand break formation reveals extremely low repair by homologous recombination in human cells. Oncogene, 31(30):3495-504

    Link to PDF Cohen-Carmon D and Meshorer E (2012) Polyglutamine (polyQ) disorders: The chromatin connection. Nucleus, 3(5):433-41

    Link to PDF Biran A and Meshorer E (2012) Chromatin and genome organization in reprogramming. Stem Cells, 30(9):1793-9

    Link to PDF Sailaja BS, Takizawa T and Meshorer E (2012) Chromatin immunoprecipitation in mouse hippocampal cells and tissues. Methods Mol Biol, 809:353-64.

    2011
    Link to PDF Mattout A, Biran A and Meshorer E (2011) Global epigenetic changes during somatic cell reprogramming to iPS cells. J Mol Cell Biol, 3(6):341-50. [Cover]

    Link to PDF Hezroni H, Sailaja BS and Meshorer E (2011) Pluripotency-related, VPA-induced genome-wide H3K9 acetylation patterns in embryonic stem cells. J Biol Chem, 286:35977-88.

    Link to PDF Hezroni H, Tzchori I, Davidi A, Mattout A, Biran A, Nissim-Rafinia M, Westphal H and Meshorer E (2011) H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells. Nucleus, 2(4):300-309.

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    Nissim-Rafinia M and Meshorer E (2011) Photobleaching Assays (FRAP & FLIP) to Measure Chromatin Protein Dynamics in Living Embryonic Stem Cells. JoVE. 52.

    Link to PDF Gaspar-Maia A, Alajem A, Meshorer E and Ramalho-Santos M (2011) Open chromatin in pluripotency and reprogramming. Nat Rev Mol Cell Biol. 12:36-47

    2010
    Link to PDF Melcer S and Meshorer E (2010) Chromatin plasticity in pluripotent cells. Essays Biochem 48(1): 245-62.

    Link to PDF Melcer S and Meshorer E (2010) The silence of the LADs: dynamic genome-lamina interactions during ESC differentiation. Cell Stem Cell, 6:495-7.

    Link to PDF Mattout A and Meshorer E (2010) Chromatin plasticity and genome organization in pluripotent embryonic stem cells. Curr Opin Cell Biol, 22:334-41

    2009
    Link to PDF Gaspar-Maia A, Alajem A, Heidersbach A, McManus MT, Meshorer E and Ramalho-Santos M (2009) Chd1 regulates open chromatin and pluripotency of ES cells. Nature, 460:863-8

    Link to PDF Schwartz S, Meshorer E and Ast G (2009) Chromatin structure marks exon-intron architecture. Nat Struct Mol Biol, 16:990-995 [Cover]

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    • When chromatin meets splicing / Nat Struct Mol Biol


    Link to PDF Raghu Ram E and Meshorer E (2009) Transcriptional competence in pluripotency. Genes Dev, 23:2393-8

    Link to PDF Meshorer and Gruenbaum (2009) NURD keeps chromatin young. Nat Cell Biol, 11:1176-1177

    Link to PDF Prokocimer M, Davidovich M, Nissim-Rafinia M, Wiesel-Motiuk N, Bar D, Barkan R, Meshorer E and Gruenbaum Y (2009) Nuclear lamins: key regulators of nuclear structure and activities. J Cell Mol Med, 13:1059-85

    Link to PDF Efroni, S, Melcer S, Nissim-Rafinia M and Meshorer E (2009) Cells do play with dice: a statistical physics view of transcription. Cell Cycle. 8:43-48.

    2008
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    Efroni S, Duttagupta R, Cheng J, Dehghani H, Hoeppner DJ, Dash C, Bazett-Jones DP, Le Grice S, McKay RDG, Buetow KH, Gingeras TR, Misteli T and Meshorer E (2008) Global transcription in pluripotent embryonic stem cells. Cell Stem Cell, 2:437-447.

    Preview:
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    • Open chromatin and hypertranscription in embryonic stem cells / Cell Stem Cell



    Link to PDF Meshorer E (2008) Imaging chromatin in embryonic stem cells. StemBook, http://www.stembook.org.

    Link to PDF Meshorer E and Gruenbaum Y (2008) Rejuvenating premature aging disease. Nat Med. 14:713-715.

    Link to PDF Takizawa T and Meshorer E (2008) Chromatin and nuclear architecture in the central nervous system. Trends Neurosci. 31:343-352.

    Link to PDF Meshorer E and Gruenbaum Y (2008) Gone with the Wnt/Notch: stem cells in laminopathies, progeria and aging. J Cell Biol. 181:9-13.

    2007
    Link to PDF Meshorer E (2007) Chromatin in embryonic stem cell neuronal differentiation. Histol. Histopathol. 22:311-319.

    2006
    Link to PDF Meshorer E, Yellajoshula D, George E, Scambler PJ, Brown D and Misteli T (2006) Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell, 10:105-116.

    Previews:
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    • Breathing chromatin in ES cells / Dev Cell


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    • Hyperdynamic proteins keep stem cells on their toes / J Cell Biol


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    • The open secret of pluripotency / Nat Rev Genet


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    • Movers and shakers in embryonic stem cell chromatin / Cell


    Link to PDF Meshorer E and Misteli T (2006) Chromatin in pluripotency and embryonic stem cell differentiation. Nat Rev Mol Cell Biol. 7:540-546

    Link to PDF Meshorer E and Soreq H (2006) Virtues and woes of acetylcholinesterase alternative splicing in stress related neuropathology. Trends Neurosci. 29:216-224

    2005 and earlier
    Link to PDF Meshorer E, Bryk B, Toiber D, Cohen J, Podoly E, Dori A and Soreq H (2005) SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA. Mol. Psych. 10:985-997. [Lilly award winner. Cover]

    Link to PDF Meshorer E, Biton I, Ben-Shaul Y, Assaf Y, Soreq H and Cohen Y (2005) Brain diffusion and transport abnormalities under cholinergic imbalance. FASEB J. 19:910-22

    Link to PDF Meshorer E and Misteli T (2005) Splicing misplaced. Cell, 122:317-318

    Link to PDF Meshorer E, Toiber D, Zurel D, Sahly I, Dori A, Cagnano E, Schreiber L, Grisaru D, Tronche F and Soreq H (2004) Combinatorial Complexity of 5’ Alternative ACHE Transcripts and Protein Products. J. Biol. Chem. 279:29740-29751

    Link to PDF Stoilov P*, Meshorer E*, Gencheva M, Glick D, Soreq H and Stamm S (2002) Defects in pre-mRNA processing as causes of and predisposition to diseases. DNA Cell Biol. 21:803-81

    Link to PDF Meshorer E and Soreq H (2002) Pre-mRNA splicing modulations in senescence. Aging Cell 1:10-16 [Cover]

    Link to PDF Meshorer E, Erb C, Gazit R, Pavlovsky L, Kaufer D, Friedman A, Glick D, Ben-Arie N and Soreq H (2002) Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science, 295:508-512.

     

   

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